Naphthoquinones from the Roots of Aloe Secundiflora
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Phytochemistry Letters
Abstract
Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy- 3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene- 1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21– 23 mg/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5- hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell
line (IC50 = 10.2 mg/mL).
Description
Keywords
Aloe secundiflora, Asphodelaceae, Roots, Naphthoquinone, Anthraquinone, Aloesaponarin I, Mycobacterium tuberculosis
Citation
Induli, M., Cheloti, M., Wasuna, A., Wekesa, I., Wanjohi, J. M., Byamukama, R., ... & Yenesew, A. (2012). Naphthoquinones from the roots of Aloe secundiflora. Phytochemistry Letters, 5(3), 506-509.http://dx.doi.org/10.1016/j.phytol.2012.04.014