Reversal of the Kynurenine Pathway of Tryptophan Catabolism May Improve Depression in ART-Treated HIV-Infected Ugandans

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dc.contributor.authorMartinez, Priscilla
dc.contributor.authorTsai, Alexander C.
dc.contributor.authorMuzoora, Conrad
dc.contributor.authorKembabazi, Annet
dc.contributor.authorWeiser, Sheri D.
dc.contributor.authorHuang, Yong
dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorMartin, Jeffrey N.
dc.contributor.authorBangsberg, David R.
dc.contributor.authorHunt, Peter W.
dc.date.accessioned2022-01-31T16:04:17Z
dc.date.available2022-01-31T16:04:17Z
dc.date.issued2014
dc.description.abstractMajor depressive disorder is highly prevalent among HIV-infected persons, and depression symptom severity improves during the course of HIV antiretroviral therapy (ART). The potential biologic pathways explaining these phenomena remain unclear. We investigated the extent to which ART-mediated suppression of the kynurenine pathway of tryptophan catabolism (via indoleamine 2,3- dioxygenase-1 and potentially other sources) may correlate with improvements in depression symptom severity in this setting.en_US
dc.identifier.citationMartinez, P., Tsai, A. C., Muzoora, C., Kembabazi, A., Weiser, S. D., Huang, Y., ... & Hunt, P. W. (2014). Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans. Journal of acquired immune deficiency syndromes (1999), 65(4), 456.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943704/
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1689
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectTryptophan catabolismen_US
dc.subjectIndoleamine 2en_US
dc.subject3-dioxygenase-1en_US
dc.subjectDepressionen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectSub-Saharan Africaen_US
dc.titleReversal of the Kynurenine Pathway of Tryptophan Catabolism May Improve Depression in ART-Treated HIV-Infected Ugandansen_US
dc.typeArticleen_US
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