Reversal of the Kynurenine Pathway of Tryptophan Catabolism May Improve Depression in ART-Treated HIV-Infected Ugandans
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Date
2014
Authors
Martinez, Priscilla
Tsai, Alexander C.
Muzoora, Conrad
Kembabazi, Annet
Weiser, Sheri D.
Huang, Yong
Haberer, Jessica E.
Martin, Jeffrey N.
Bangsberg, David R.
Hunt, Peter W.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of acquired immune deficiency syndromes
Abstract
Major depressive disorder is highly prevalent among HIV-infected persons, and depression symptom severity improves during the course of HIV antiretroviral therapy (ART). The potential biologic pathways explaining these phenomena remain unclear. We investigated the extent to which ART-mediated suppression of the kynurenine pathway of tryptophan catabolism (via indoleamine 2,3- dioxygenase-1 and potentially other sources) may correlate with improvements in depression symptom severity in this setting.
Description
Keywords
Tryptophan catabolism, Indoleamine 2, 3-dioxygenase-1, Depression, Antiretroviral therapy, Sub-Saharan Africa
Citation
Martinez, P., Tsai, A. C., Muzoora, C., Kembabazi, A., Weiser, S. D., Huang, Y., ... & Hunt, P. W. (2014). Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans. Journal of acquired immune deficiency syndromes (1999), 65(4), 456.