Surgery for Colorectal Cancer Improves Survival in Uganda: A Cohort Study

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dc.contributor.authorWismayer, Richard
dc.contributor.authorKiwanuka, Julius
dc.contributor.authorWabinga, Henry
dc.contributor.authorOdida, Michael
dc.date.accessioned2023-02-28T09:05:50Z
dc.date.available2023-02-28T09:05:50Z
dc.date.issued2022
dc.description.abstractColorectal carcinoma (CRC) incidence and mortality rates are rising in Uganda and other developing low-income nations in Sub-Saharan Africa, while CRC rates are dropping in high-income industrialized countries. In Uganda, many people with CRC do not have access to curative surgery or oncological care. To analyze the impact of surgery and oncology care on CRC in the resource-limited environment of a low-income developing nation, we compared the survival results of patients who underwent curative surgery and, if necessary, adjuvant chemotherapy to those who did not. The study included people who were diagnosed with CRC between January 1, 2008, and December 31, 2018. The Kampala Cancer Registry and medical records from Ugandan hospitals were linked for these patients. The researchers wanted to know if the individuals had had curative surgery and adjuvant treatment. Our outcome variable was survival at 3 years. The log-rank test was used to calculate and compare survival. A total of 247 patients were involved in the study. There were 177 (71.66 %) patients who received curative surgery and 70 (28.34 %) who did not. Curative rectal cancer surgery had a better survival than no curative surgery (p=0.003). Curative colon cancer surgery tended to have a better survival than no surgery (p=0.137). Curative surgery and adjuvant chemotherapy showed better survival than no surgery with no adjuvant chemotherapy (p=0.007). Curative surgery, if necessary, paired with adjuvant chemotherapy, improves survival in a resource-constrained situation. As a result of the increasing burden of CRC, the findings of our study serve to support the extension of CRC care by upgrading surgery and oncology infrastructure in resource-limited areas.en_US
dc.identifier.citationWismayer, R., Kiwanuka, J., Wabinga, H., & Odida, M. (Current Practice in Medical Science). Surgery for Colorectal Cancer Improves Survival in Uganda: A Cohort Study. Current Practice in Medical Science Vol. 4, 1-14.en_US
dc.identifier.isbn978-93-5547-548-0
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8013
dc.language.isoenen_US
dc.publisherCurrent Practice in Medical Scienceen_US
dc.subjectColorectal canceren_US
dc.subjectlow-income developing countryen_US
dc.subjectcurative surgeryen_US
dc.subjectadjuvant chemotherapyen_US
dc.titleSurgery for Colorectal Cancer Improves Survival in Uganda: A Cohort Studyen_US
dc.typeBook chapteren_US
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