Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

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dc.contributor.authorKakande, Elijah
dc.contributor.authorGreenhouse, Bryan
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorDrakeley, Chris
dc.contributor.authorNankabirwa, Joaniter I.
dc.contributor.authorWalakira, Andrew
dc.contributor.authorNsobya, Samuel L.
dc.contributor.authorKatureebe, Agaba
dc.contributor.authorRek, John
dc.contributor.authorArinaitwe, Emmanuel
dc.contributor.authorRosenthal, Philip J.
dc.contributor.authorKamya, Moses R.
dc.contributor.authorDorsey, Grant
dc.contributor.authorRodriguez‑Barraquer, Isabel
dc.date.accessioned2021-12-15T10:28:06Z
dc.date.available2021-12-15T10:28:06Z
dc.date.issued2020
dc.description.abstractMultiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quantify associations between three red blood cell variants Hb [AA, AS, S (rs334)], alpha thalassaemia 3.7 kb deletion, and glucose-6-phosphate dehydrogenase deficiency A—(G6PD 202A genotype) and malaria incidence, parasite prevalence, parasite density (a measure of anti-parasite immunity) and body temperature adjusted for parasite density (a measure of anti-disease immunity). All analyses were adjusted for age, average household entomological inoculation rate, and study site. Results for all variants were compared to those for wild type genotypes.en_US
dc.identifier.citationKakande, E., Greenhouse, B., Bajunirwe, F. et al. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. Malar J 19, 21 (2020). https://doi.org/10.1186/s12936-020-3105-3en_US
dc.identifier.issn1475-2875
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/574
dc.language.isoenen_US
dc.publisherMalaria Journalen_US
dc.subjectRed blood cell variants, Erythrocyte, Malaria, Plasmodium, Sickle hemoglobin, Thalassemiaen_US
dc.titleAssociations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort studyen_US
dc.typeArticleen_US
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