Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Malaria Journal
Abstract
Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear.
Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quantify associations between three red blood cell variants Hb [AA, AS, S (rs334)], alpha thalassaemia 3.7 kb deletion, and glucose-6-phosphate dehydrogenase deficiency A—(G6PD 202A genotype) and malaria incidence, parasite prevalence, parasite density (a measure of anti-parasite immunity) and body temperature adjusted for parasite density (a measure of anti-disease immunity). All analyses were adjusted for age, average household entomological inoculation rate, and study site. Results for all variants were compared to those for wild type genotypes.
Description
Keywords
Red blood cell variants, Erythrocyte, Malaria, Plasmodium, Sickle hemoglobin, Thalassemia
Citation
Kakande, E., Greenhouse, B., Bajunirwe, F. et al. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. Malar J 19, 21 (2020). https://doi.org/10.1186/s12936-020-3105-3