Asymptomatic bacteriuria among pregnant women attending antenatal care at Mbale Hospital, Eastern Uganda
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
PloS one
Abstract
Asymptomatic bacteriuria in pregnancy (ASBP) is associated with adverse pregnancy outcomes
such as pyelonephritis, preterm or low birth weight delivery if untreated. The aim of
this study was to determine the prevalence of asymptomatic bacteriuria, the isolated bacterial
agents, and their antibiotic sensitivity patterns in pregnant women attending antenatal
care at Mbale Hospital.
Methods
This was a cross sectional study in which 587 pregnant women with no symptoms and signs
of urinary tract infection were recruited from January to March 2019. Mid-stream clean catch
urine samples were collected from the women using sterile containers. The urine samples
were cultured using standard laboratory methods. The bacterial colonies were identified and
antibiotic sensitivity was done using disc diffusion method. Chi squared tests and logistic
regression were done to identify factors associated with asymptomatic bacteriuria. A p value
< 0.05 was considered statistically significant.
Results
Out of the 587 pregnant women, 22 (3.75%) tested positive for asymptomatic bacteriuria.
Women aged 20–24 years were less likely to have ASBP when compared to women aged
less than 20 years (AOR = 0.14, 95%CI 0.02–0.95, P = 0.004). The most common isolates
in descending order were E. coli (n = 13, 46.4%) and S.aureus (n = 9, 32.1%). Among the
gram negative isolates, the highest sensitivity was to gentamycin (82.4%) and imipenem
(82.4%). The gram positive isolates were sensitive to gentamycin (90.9%) followed by imipenem
(81.8%). All the isolates were resistant to sulphamethoxazole with trimethoprim (100%). Multidrug resistance was 82.4% among gram negative isolates and 72.4% among
the gram positive isolates.
Conclusion
There was high resistance to the most commonly used antibiotics. There is need to do urine
culture and sensitivity from women with ASBP so as to reduce the associated
complications.
Description
Keywords
Asymptomatic bacteriuria, Pregnant women, Antenatal care, Mbale Hospital
Citation
Nteziyaremye J, Iramiot SJ, Nekaka R, Musaba MW, Wandabwa J, Kisegerwa E, et al. (2020) Asymptomatic bacteriuria among pregnant women attending antenatal care at Mbale Hospital, Eastern Uganda. PLoS ONE 15(3): e0230523. https://doi.org/10.1371/journal.pone.0230523