Prevalence and Correlates of Mycoplasma genitalium Infection Among Female Sex Workers in Kampala, Uganda
Loading...
Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Infectious Diseases
Abstract
The importance of Mycoplasma genitalium in human immunodeficiency virus (HIV)–burdened
sub–Saharan Africa is relatively unknown. We assessed the prevalence and explored determinants of this emerging
sexually transmitted infection (STI) in high-risk women in Uganda.
Methods. Endocervical swabs from 1025 female sex workers in Kampala were tested for Mycoplasma genitalium
using a commercial Real-TM polymerase chain reaction assay. Factors associated with prevalent Mycoplasma
genitalium, including sociodemographics, reproductive history, risk behavior, and HIV and other STIs, were examined
using multivariable logistic regression.
Results. The prevalence of Mycoplasma genitalium was 14% and higher in HIV-positive women than in HIVnegative
women (adjusted odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12–2.41). Mycoplasma genitalium
infection was less prevalent in older women (adjusted OR, 0.61; 95% CI, .41–.90 for women ages 25–34 years vs
,25 years; adjusted OR, 0.32; 95% CI, .15–.71 for women $35 years vs those ,25 years) and in those who had been
pregnant but never had a live birth (adjusted OR, 2.25; 95% CI, 1.04–4.88). Mycoplasma genitalium was associated
with Neisseria gonorrhoeae (adjusted OR, 1.84; 95% CI, 1.13–2.98) and with Candida infection (adjusted OR, 0.41;
95% CI, .18–.91), and there was some evidence of association with Trichomonas vaginalis (adjusted OR, 1.56; 95%
CI, 1.00–2.44).
Conclusions. The relatively high prevalence of Mycoplasma genitalium and its association with prevalent HIV
urgently calls for further research to explore the potential role this emerging STI plays in the acquisition and
transmission of HIV infection.
Description
Keywords
Prevalence, Mycoplasma genitalium Infection, Female Sex Workers, Uganda
Citation
Vandepitte, J., Muller, E., Bukenya, J., Nakubulwa, S., Kyakuwa, N., Buvé, A., ... & Grosskurth, H. (2012). Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda. Journal of Infectious Diseases, 205(2), 289-296.