High pathogenicity and low genetic evolution of avian paramyxovirus type I (Newcastle disease virus) isolated from live bird markets in Uganda

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dc.contributor.authorByarugaba, Denis K.
dc.contributor.authorMugimba, Kizito K.
dc.contributor.authorOmony, John B.
dc.contributor.authorOkitwi, Martin
dc.contributor.authorWanyana, Agnes
dc.contributor.authorOtim, Maxwell O.
dc.contributor.authorKirunda, Halid
dc.contributor.authorNakavuma, Jessica L.
dc.contributor.authorTeillaud, Angélique
dc.contributor.authorPaul, Mathilde C.
dc.contributor.authorDucatez, Mariette F.
dc.date.accessioned2022-12-13T12:57:47Z
dc.date.available2022-12-13T12:57:47Z
dc.date.issued2014
dc.description.abstractNewcastle disease is still a serious disease of poultry especially in backyard free-range production systems despite the availability of cross protective vaccines. Healthy-looking poultry from live bird markets have been suspected as a major source of disease spread although limited studies have been conducted to ascertain the presence of the virulent strains in the markets and to understand how they are related to outbreak strains. Methods: This study evaluated the occurrence of Newcastle disease virus in samples collected from poultry in live bird markets across Uganda. The isolates were pathoyped using standard methods (mean death time (MDT), intracelebral pathogenicity index (ICPI), and sequencing of the fusion protein cleavage site motif) and also phylogenetically analysed after sequencing of the full fusion and hemagglutin-neuraminidase genes. The isolates were classified into genotypes and subgenotypes based on the full fusion protein gene classification system and compared with other strains in the region and world-wide. Results: Virulent avian paramyxovirus type I (APMV-1) (Newcastle disease virus) was isolated in healthy-looking poultry in live bird markets. The viruses belonged to a new subgenotype, Vd, in genotype V, and clustered together with Tanzania and Kenya strains. They harbored low genetic diversity. Conclusion: The occurrence of virulent AMPV-1 strains in live bird markets may serve as sources of Newcastle disease outbreaks in non-commercial farmsen_US
dc.identifier.citationByarugaba, D. K., Mugimba, K. K., Omony, J. B., Okitwi, M., Wanyana, A., Otim, M. O., ... & Ducatez, M. F. (2014). High pathogenicity and low genetic evolution of avian paramyxovirus type I (Newcastle disease virus) isolated from live bird markets in Uganda. Virology Journal, 11(1), 1-13.en_US
dc.identifier.urihttps://link.springer.com/article/10.1186/1743-422X-11-173
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6242
dc.language.isoenen_US
dc.publisherVirology Journalen_US
dc.subjectNewcastle disease virusen_US
dc.subjectLive bird marketsen_US
dc.subjectGenetic diversityen_US
dc.titleHigh pathogenicity and low genetic evolution of avian paramyxovirus type I (Newcastle disease virus) isolated from live bird markets in Ugandaen_US
dc.typeArticleen_US
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