Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children

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dc.contributor.authorPetrone, Linda
dc.contributor.authorCannas, Angela
dc.contributor.authorAloi, Francesco
dc.contributor.authorNsubuga, Martin
dc.contributor.authorSserumkuma, Joseph
dc.contributor.authorNazziwa, Ritah Angella
dc.contributor.authorJugheli, Levan
dc.contributor.authorLukindo, Tedson
dc.contributor.authorGirardi, Enrico
dc.contributor.authorReither, Klaus
dc.contributor.authorGoletti, Delia
dc.date.accessioned2022-05-04T14:00:17Z
dc.date.available2022-05-04T14:00:17Z
dc.date.issued2015
dc.description.abstractInterferon-𝛾 inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker for adults. This study aims to evaluate the potential of IP-10 diagnostics in children from Uganda, a high TB-endemic country. Methods. IP-10 was measured in the blood and urine concomitantly taken from children who were prospectively enrolled with suspected active TB, with or without HIV infection. Clinical/microbiological parameters and commercially available TB-immune assays (tuberculin skin test (TST) and QuantiFERON TB-Gold In-Tube (QFT-IT)) were concomitantly evaluated. Results. One hundred twenty-eight childrenwere prospectively enrolled.The analysiswas performed on 111 children: 80 (72%) of themwere HIVuninfected and 31 (27.9%) were HIV-infected. Thirty-three healthy adult donors (HAD) were included as controls. The data showed that IP-10 is detectable in the urine and blood of children with active TB, independent of HIV status and age. However, although IP-10 levels were higher in active TB children compared to HAD, the accuracy of identifying “active TB” was low and similar to the TST and QFT-IT. Conclusion. IP-10 levels are higher in children with respiratory illness compared to controls, independent of “TB status” suggesting that the evaluation of this parameter can be used as an inflammatory marker more than a TB test.en_US
dc.identifier.citationPetrone, L., Cannas, A., Aloi, F., Nsubuga, M., Sserumkuma, J., Nazziwa, R. A., ... & Goletti, D. (2015). Blood or urine IP-10 cannot discriminate between active tuberculosis and respiratory diseases different from tuberculosis in children. BioMed research international, 2015. http://dx.doi.org/10.1155/2015/589471en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2015/589471
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3195
dc.language.isoenen_US
dc.publisherBioMed research internationalen_US
dc.subjectBlooden_US
dc.subjectUrine IP-10en_US
dc.subjectTuberculosis and Respiratory Diseasesen_US
dc.subjectTuberculosisen_US
dc.subjectChildrenen_US
dc.titleBlood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Childrenen_US
dc.typeArticleen_US
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