Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed research international
Abstract
Interferon-𝛾 inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker
for adults. This study aims to evaluate the potential of IP-10 diagnostics in children from Uganda, a high TB-endemic country.
Methods. IP-10 was measured in the blood and urine concomitantly taken from children who were prospectively enrolled with
suspected active TB, with or without HIV infection. Clinical/microbiological parameters and commercially available TB-immune
assays (tuberculin skin test (TST) and QuantiFERON TB-Gold In-Tube (QFT-IT)) were concomitantly evaluated. Results. One
hundred twenty-eight childrenwere prospectively enrolled.The analysiswas performed on 111 children: 80 (72%) of themwere HIVuninfected
and 31 (27.9%) were HIV-infected. Thirty-three healthy adult donors (HAD) were included as controls. The data showed
that IP-10 is detectable in the urine and blood of children with active TB, independent of HIV status and age. However, although
IP-10 levels were higher in active TB children compared to HAD, the accuracy of identifying “active TB” was low and similar to the
TST and QFT-IT. Conclusion. IP-10 levels are higher in children with respiratory illness compared to controls, independent of “TB
status” suggesting that the evaluation of this parameter can be used as an inflammatory marker more than a TB test.
Description
Keywords
Blood, Urine IP-10, Tuberculosis and Respiratory Diseases, Tuberculosis, Children
Citation
Petrone, L., Cannas, A., Aloi, F., Nsubuga, M., Sserumkuma, J., Nazziwa, R. A., ... & Goletti, D. (2015). Blood or urine IP-10 cannot discriminate between active tuberculosis and respiratory diseases different from tuberculosis in children. BioMed research international, 2015. http://dx.doi.org/10.1155/2015/589471