Neuroprotective Potential of Lantana Trifolium Ethanolic Extract against Ethambutol Induced Histological Changes in the Optic Nerve

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dc.contributor.authorOwembabazi, Elna
dc.contributor.authorNinsiima, Herbert Izo
dc.contributor.authorMario, Edgar Fernandez Diaz
dc.contributor.authorEchoru, Isaac
dc.contributor.authorLemuel, Ann Monima
dc.contributor.authorAhimbisibwe, James
dc.contributor.authorBukenya, Edmund
dc.date.accessioned2023-05-15T17:39:31Z
dc.date.available2023-05-15T17:39:31Z
dc.date.issued2017
dc.description.abstractEthambutol is an anti-tuberculosis drug important in treatment of multidrug resistant tuberculosis which is on a rise due to emergence of Human Immunodeficiency Virus. However, it has been associated with side effects on optic nerve histology leading to severe neuropathy. The purpose of this study was to establish the protective potential of Lantana trifolium ethanolic extract against ethambutol induced histological changes in the optic nerve. Twenty five male adult wistar rats of 110-130g average weight were used. These were divided into five groups each comprising five animals. Group A received distilled water only. Group B was treated with 100 mg/kg/day of ethambutol. Groups C, D, and E were treated with 25, 50, and 100 mg/kg/day of Trifolium Extract respectively, one hour before administering 100 mg/kg/day of ethambutol. After five weeks the optic nerves were excised, processed and stained for histological studies. It was observed that Lantana trifolium ethanolic extract had a dose dependent protective potential against ethambutol induced histological changes in the optic nerve. The histology of the optic nerve showed that the numbers of vacuoles were significantly few in group A (2.2±0.37), D (6.2±1.07), and E (5±0.71) when compared against the positive control group (37.4±1.54). Axons were mildly demyelinated in group D and E compared to group B and C. The protective potential of Latana trifolium is possibly present due to its anti-oxidative and anti-inflammatory activities. Studies to determine the exact phytochemical component and mechanism of action responsible for the neuroprotective potential of Latana trifolium should be conducted.en_US
dc.identifier.citationOwembabazi E, Ninsiima HI, Mario EFD, Echoru I, Lemuel AM, Ahimbisibwe J, Bukenya E. Neuroprotective Potential of Lantana Trifolium Ethanolic Extract against Ethambutol Induced Histological Changes in the Optic Nerve. Anatomy Journal of Africa. 6: 1071-1080.en_US
dc.identifier.urihttps://www.ajol.info/index.php/aja/article/view/163515
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8704
dc.language.isoenen_US
dc.publisherAnatomy Journal of Africaen_US
dc.subjectEthambutolen_US
dc.subjectOptic Nerveen_US
dc.subjectLantana Trifoliumen_US
dc.subjectOptic Neuropathyen_US
dc.titleNeuroprotective Potential of Lantana Trifolium Ethanolic Extract against Ethambutol Induced Histological Changes in the Optic Nerveen_US
dc.typeArticleen_US
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