Modelling hepatotoxicity and antiretroviral therapeutic effect in HIV/HBV coinfection

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dc.contributor.authorLuboobi, Livingstone S.
dc.contributor.authorNampala, Hasifa
dc.contributor.authorMugisha, Joseph Y.T.
dc.contributor.authorObua, Celestino
dc.contributor.authorSabuka, Matylda Jablonska
dc.date.accessioned2022-03-10T16:25:27Z
dc.date.available2022-03-10T16:25:27Z
dc.date.issued2018
dc.description.abstractEnzyme alanine aminotransferase (ALT) elevation which reflects hepatocellular injury is a current challenge in people infected with human immunodeficiency virus (HIV) on antiretroviral therapy (ART). One of the factors that enhance the risk of hepatotoxicity is underlying diseases such as hepatitis caused by hepatitis B virus (HBV). HIV/HBV coinfected patients stand a greater risk of hepatotoxicity because all ART are toxic and liver cells (hepatocytes) that are responsible for metabolising the toxic ART, support all stages of HIV and HBV viral production. Mathematical models coupled with numerical simulations are used in this study with the aim of investigating the optimal combination of ART in HIV/HBV coinfection. Emtricitabine, tenofovir and efavirenz is the optimal combination that maximises the therapeutic effect of therapy and minimises the toxic response to medication in HIV/HBV coinfection.en_US
dc.identifier.citationNampala, H., Luboobi, L. S., Mugisha, J. Y., Obua, C., & Jablonska-Sabuka, M. (2018). Modelling hepatotoxicity and antiretroviral therapeutic effect in HIV/HBV coinfection. Mathematical biosciences, 302, 67-79doi:10.1016/j.mbs.2018.05.012.en_US
dc.identifier.urihttps://doi.org/10.1016/j.mbs.2018.05.012
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2653
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectModelling hepatotoxicityen_US
dc.subjectAntiretroviral therapeutic effecten_US
dc.subjectHIV/HBV coinfectionen_US
dc.titleModelling hepatotoxicity and antiretroviral therapeutic effect in HIV/HBV coinfectionen_US
dc.typeArticleen_US
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