Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
BMJ Open
Abstract
To assess extent and determinants of past month recognition of suspected adverse drug reactions (ADR) and past-year ADR reporting among healthcare professionals (HCPs) in Uganda. Setting: Geographically diverse health facilities (public, private for-profit, private not-for-profit). Participants: Of 2000 questionnaires distributed, 1345 were completed: return rate of 67%.
Primary and secondary outcome measures: Per cent HCPs who suspected ADR in the past month; reported ADR in the past year.
Results: Nurses were the majority (59%, 792/1345). Only half the respondents had heard about
pharmacovigilance: 39% of nurses (295/763; 95% CI 35% to 42%), 70% otherwise (383/547; 95% CI 66%
to 74%). One fifth (268/1289 or 21%; 95% CI 19% to 23%) had suspected an ADR in the previous 4 weeks,
111 of them were nurses; 15% (190/1296) had reported a suspected ADR in the past year, 103 of
them were nurses. Past-month ADR suspicion was more likely by non-nurses (OR=1.7, 95% CI 1.16 to
2.40) and with medical research involvement (OR=1.5, 95% CI 1.05 to 2.15) but past-month receipt of patient
ADR-complaint predominated (OR=19, 95% CI 14 to 28). Past-year ADR reporting was higher by hospital
staff (OR=1.9, 95% CI 1.18 to 3.10), especially in medicine (OR=2.3, 95% CI 1.08 to 4.73); but lower
from private for-profit health facilities (OR=0.5, 95% CI 0.28 to 0.77) and by older staff (OR=0.6, 95% CI 0.43
to 0.91); more likely by HCPs who had ever encountered a fatal ADR (OR=2.9, 95% CI 1.94 to 4.25), knew to whom to report (OR=1.7, 95% CI 1.18 to 2.46), or suggested how to improve ADR reporting (OR=1.6, 95% CI 1.04 to 2.49). Two attitudinal factors were important: diffidence and lethargy.
Description
Keywords
adverse drug, healthcare professionals, Uganda
Citation
Kiguba R, Karamagi C, Waako P, et al. Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants. BMJ Open 2014;4:e005869. doi:10.1136/bmjopen-2014- 005869.doi:10.1136/bmjopen-2014- 005869