Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome

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dc.contributor.authorJjingo, Daudi
dc.contributor.authorWang, Jianrong
dc.contributor.authorConley, Andrew B.
dc.contributor.authorLunyak, Victoria V.
dc.contributor.authorJordan, I. King
dc.date.accessioned2021-12-13T15:37:34Z
dc.date.available2021-12-13T15:37:34Z
dc.date.issued2013
dc.description.abstractIt has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon. Results: To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4þ T cells.We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4þ T cells.en_US
dc.identifier.citationJjingo, D., Wang, J., Conley, A. B., Lunyak, V. V., & Jordan, I. K. (2013). Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome. Bioinformatics, 29(24), 3109-3112. doi:10.1093/bioinformatics/btt542en_US
dc.identifier.other10.1093/bioinformatics/btt542
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/446
dc.language.isoenen_US
dc.publisherBioinformaticsen_US
dc.subjectCompound cis-regulatory elementsen_US
dc.subjectEnhancer sequencesen_US
dc.subjectHuman genomeen_US
dc.titleCompound cis-regulatory elements with both boundary and enhancer sequences in the human genomeen_US
dc.typeArticleen_US
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