Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei bru

Simple item page
dc.contributor.authorNanteza, Ann
dc.contributor.authorNsadha, Zachary
dc.contributor.authorNamayanja, Monica
dc.contributor.authorLubega, G.William
dc.date.accessioned2023-03-07T07:48:38Z
dc.date.available2023-03-07T07:48:38Z
dc.date.issued2020
dc.description.abstractInvasion of the Central Nervous System (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. The study aimed ats assessing the role of tubulin vaccine candidate in protection of cattle against trypanosomiasis using Trypanosoma brucei brucei subspecies that is highly related to Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that cause sleeping sickness in man. The tissue behavior and cerebral fate of T. b. brucei in cattle should mimic the situation in humans and since cattle are also natural hosts for trypanosomes, it was envisaged that the cattle system would be a more suitable model for vaccination studies than the rodent model. Experimental infection of tubulin vaccine candidate vaccinated and non-vaccinated Ankole long horn cattle breed calves was done using a Trypanosoma brucei brucei parasite strain that had been previously isolated from naturally infected cattle in Uganda. Trypanosomiasis disease progression and associated pathology were assessed by clinical and extensive post mortem examinations. Marked organ abnormalities and severe lesions were observed in the non-vaccinated cattle, however, the findings revealed that tubulin vaccination in cattle lowers tissue parasitiasis and ameliorates the inflammatory pathology and clinical signs of trypanosomiasis by Trypanosoma brucei brucei. The trypanosome tissue invasion may be susceptible to immunological attenuation.en_US
dc.identifier.citationNanteza, A., Nsadha, Z., Namayanja, M., & Lubega, G. W. (2020). Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei brucei. J Vaccines Immunol, 5, 149. DOI: 10.29011/2575-789X.000149en_US
dc.identifier.issn2575-789X
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8097
dc.language.isoenen_US
dc.publisherJ Vaccines Immunolen_US
dc.subjectAnkole cattleen_US
dc.subjectVaccinationen_US
dc.subjectCentral nervous systemen_US
dc.subjectPathologyen_US
dc.subjectTrypanosoma brucei bruceien_US
dc.subjectTubulinen_US
dc.titleTubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei bruen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei brucei.pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format
Description:
Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei brucei
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Agricultural and Veterinary Sciences