Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei bru
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
J Vaccines Immunol
Abstract
Invasion of the Central Nervous System (CNS) by African trypanosomes represents a critical step in the development
of human African trypanosomiasis. The study aimed ats assessing the role of tubulin vaccine candidate in protection of cattle
against trypanosomiasis using Trypanosoma brucei brucei subspecies that is highly related to Trypanosoma brucei gambiense
and Trypanosoma brucei rhodesiense that cause sleeping sickness in man. The tissue behavior and cerebral fate of T. b. brucei
in cattle should mimic the situation in humans and since cattle are also natural hosts for trypanosomes, it was envisaged that
the cattle system would be a more suitable model for vaccination studies than the rodent model. Experimental infection of
tubulin vaccine candidate vaccinated and non-vaccinated Ankole long horn cattle breed calves was done using a Trypanosoma
brucei brucei parasite strain that had been previously isolated from naturally infected cattle in Uganda. Trypanosomiasis
disease progression and associated pathology were assessed by clinical and extensive post mortem examinations. Marked
organ abnormalities and severe lesions were observed in the non-vaccinated cattle, however, the findings revealed that tubulin
vaccination in cattle lowers tissue parasitiasis and ameliorates the inflammatory pathology and clinical signs of trypanosomiasis
by Trypanosoma brucei brucei. The trypanosome tissue invasion may be susceptible to immunological attenuation.
Description
Keywords
Ankole cattle, Vaccination, Central nervous system, Pathology, Trypanosoma brucei brucei, Tubulin
Citation
Nanteza, A., Nsadha, Z., Namayanja, M., & Lubega, G. W. (2020). Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei brucei. J Vaccines Immunol, 5, 149. DOI: 10.29011/2575-789X.000149