PIERS Proteinuria: Relationship With Adverse Maternal and Perinatal Outcome
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Obstetrics and Gynaecology
Abstract
To examine the ability of three different proteinuria assessment methods (urinary dipstick, spot urine protein:creatinine ratio [Pr/Cr], and 24-hour urine collection) to predict adverse pregnancy outcomes Methods: We performed a prospective multicentre cohort study, PIERS (Preeclampsia Integrated Estimate of RiSk), in seven academic tertiary maternity centres practising expectant management of preeclampsia remote from term in Canada, New Zealand, and Australia- Eligible women were those admitted with preeclampsia who had at least one antenatal proteinuria assessment by urinary
dipstick, spot urine Pr/Cr ratio, and/or 24-hour urine collection Proteinuria assessment was done either visually at the bedside (by dipstick) or by hospital clinical laboratories for spot urine Pr/Cr and 24-hour urine collection- We calculated receiver
operating characteristic area under the curve (95% CI) for each proteinuria method and each of the combined adverse maternal
outcomes (within 48 hours) or adverse perinatal outcomes (at any time) Models with AUC ≥ 0-70 were considered of interest- Analyses were run for all women who had each type of proteinuria assessment and for a cohort of women (“ALL measures”) who had all three proteinuria assessments
Description
Keywords
Proteinuria, Preeclampsia, Receiver operating characteristic curve, diagnostic accuracy, Competing Interests
Citation
Payne, B., Magee, L. A., Côté, A. M., Hutcheon, J. A., Li, J., Kyle, P. M., ... & PIERS Study Group. (2011). PIERS proteinuria: relationship with adverse maternal and perinatal outcome. Journal of Obstetrics and Gynaecology Canada, 33(6), 588-597.