Molecular basis for cytokine biomarkers of complex 3D microtissue physiology in vitro

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dc.contributor.authorAsthana, Amish
dc.contributor.authorKisaalita, William S.
dc.date.accessioned2025-04-16T11:45:36Z
dc.date.available2025-04-16T11:45:36Z
dc.date.issued2016
dc.description.abstractPhysiologically more-relevant’claims are readily made for cells cultured on any surface or in a scaffold that provides loosely defined 3D geometry. A set of tools to measure culture ‘3D-ness’ more accurately are needed. Such tools should find applications in fields ranging from high-throughput identification of substrates for tissue engineering and regenerative medicine to cell-based screening of drug candidates. Until now, these fields have not provided a consensus for the most promising place to initiate the search. Here, we review recent advances in transcriptomic, proteomic, inflammation and oncology-related pathways, as well as functional studies that strongly point to cytokines as the most likely compounds to form the missing consensus.
dc.identifier.citationAsthana, A., & Kisaalita, W. S. (2016). Molecular basis for cytokine biomarkers of complex 3D microtissue physiology in vitro. Drug discovery today, 21(6), 950-961.
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.drudis.2016.03.009
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10810
dc.language.isoen
dc.publisherDrug discovery today
dc.titleMolecular basis for cytokine biomarkers of complex 3D microtissue physiology in vitro
dc.typeArticle
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