Bioactive compounds in the stem bark of Albizia coriaria (Welw. ex Oliver)

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dc.contributor.authorByamukama, Robert
dc.contributor.authorBarbara, Ganza
dc.contributor.authorNamukobe, Jane
dc.contributor.authorHeydenreich, Matthias
dc.contributor.authorKiremire, Bernard T.
dc.date.accessioned2021-12-13T12:51:31Z
dc.date.available2021-12-13T12:51:31Z
dc.date.issued2015
dc.description.abstractAlbizia coriaria was investigated for the bioactive compounds present in its stem bark. The plant was selected on the basis of its widespread use in traditional herbal medicine. Extraction of the plant material was done with ethyl acetate, methanol and water and the bioactivity of each extract was tested against Pseudomonas aeruginosa and Escherichia coli. Separation and purification of the compounds in the most active (ethyl acetate) extract was done using a combination of chromatographic techniques. The compounds were identified by 1D and 2D -1H and 13C NMR techniques as well as Mass spectrometry (MS). Six compounds, namely: Lupeol (1), Lupenone (2), Betulinic acid (3), Acacic acid lactone (4), (+) – Catechin (5) and Benzyl alcohol (6) were identified and characterized from the ethyl acetate extract. The results of the bioactivity tests carried out in this study indicated that A. coriaria has potential antimicrobial activity. Four of the characterized compounds (1, 2, 3 & 5) have a wide range of biological activity reported in literature. This justifies the use of this plant in traditional medicine and indicates a promising potential for the development of medicinal agents from A. coriaria stem bark.en_US
dc.identifier.citationByamukama, R., Barbara, G., Namukobe, J., Heydenreich, M., & Kiremire, B. T. (2015). Bioactive compounds in the stem bark of Albizia coriaria (Welw. ex Oliver). International Journal of Biological and Chemical Sciences, 9(2), 1013-1024.DOI : http://dx.doi.org/10.4314/ijbcs.v9i2.37en_US
dc.identifier.issn1997-342X (Online), ISSN 1991-8631 (Print)
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/433
dc.language.isoenen_US
dc.publisherInternational Journal of Biological and Chemical Sciencesen_US
dc.relation.ispartofseries;DOI : http://dx.doi.org/10.4314/ijbcs.v9i2.37
dc.subjectBiological activityen_US
dc.subjectLupeolen_US
dc.subjectLupenoneen_US
dc.subjectBetulinic aciden_US
dc.subjectAcacic acid lactoneen_US
dc.subject(+) – Catechin.en_US
dc.titleBioactive compounds in the stem bark of Albizia coriaria (Welw. ex Oliver)en_US
dc.typeArticleen_US
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