Bioactive compounds in the stem bark of Albizia coriaria (Welw. ex Oliver)
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Biological and Chemical Sciences
Abstract
Albizia coriaria was investigated for the bioactive compounds present in its stem bark. The plant was
selected on the basis of its widespread use in traditional herbal medicine. Extraction of the plant material was
done with ethyl acetate, methanol and water and the bioactivity of each extract was tested against
Pseudomonas aeruginosa and Escherichia coli. Separation and purification of the compounds in the most
active (ethyl acetate) extract was done using a combination of chromatographic techniques. The compounds
were identified by 1D and 2D -1H and 13C NMR techniques as well as Mass spectrometry (MS). Six
compounds, namely: Lupeol (1), Lupenone (2), Betulinic acid (3), Acacic acid lactone (4), (+) – Catechin (5)
and Benzyl alcohol (6) were identified and characterized from the ethyl acetate extract. The results of the
bioactivity tests carried out in this study indicated that A. coriaria has potential antimicrobial activity. Four of
the characterized compounds (1, 2, 3 & 5) have a wide range of biological activity reported in literature. This
justifies the use of this plant in traditional medicine and indicates a promising potential for the development of
medicinal agents from A. coriaria stem bark.
Description
Keywords
Biological activity, Lupeol, Lupenone, Betulinic acid, Acacic acid lactone, (+) – Catechin.
Citation
Byamukama, R., Barbara, G., Namukobe, J., Heydenreich, M., & Kiremire, B. T. (2015). Bioactive compounds in the stem bark of Albizia coriaria (Welw. ex Oliver). International Journal of Biological and Chemical Sciences, 9(2), 1013-1024.DOI : http://dx.doi.org/10.4314/ijbcs.v9i2.37