Mycobacterium tuberculosis Microbiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4+ -Initiated Antiretroviral Therapy in HIV-Infected Adults with a High CD4+ Cell Count
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Clinical infectious diseases
Abstract
In a prospective randomized, controlled trial in Uganda comparing the efficacy of antiretroviral therapy during tuberculosis therapy with the efficacy of tuberculosis therapy alone in HIV-infected patients with tuberculosis who have a CD4+ cell count >350 cells/µL, it was found that antiretroviral therapy did not accelerate microbiologic, radiographic, or clinical responses to tuberculosis therapy: 18% of participants had sputum smears positive for Mycobacterium tuberculosis after 5 months of tuberculosis therapy, despite having had negative culture results.
Description
Keywords
Mycobacterium tuberculosis Microbiologic, High CD4+ Cell Count, HIV-Infected Adults, Clinical Treatment Outcomes
Citation
Chamie, G., Charlebois, E. D., Srikantiah, P., Walusimbi-Nanteza, M., Mugerwa, R. D., Mayanja, H., ... & Havlir, D. V. (2010). Mycobacterium tuberculosis microbiologic and clinical treatment outcomes in a randomized trial of immediate versus CD4+-initiated antiretroviral therapy in HIV-infected adults with a high CD4+ cell count. Clinical infectious diseases, 51(3), 359-362.https://doi.org/10.1086/654799