Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

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dc.contributor.authorNamukobe, Jane
dc.contributor.authorKiremire, Bernard T.
dc.contributor.authorByamukama, Robert
dc.contributor.authorKasenene, John M.
dc.contributor.authorDumontet, Vincent
dc.contributor.authorGuéritte, Françoise
dc.contributor.authorKrief, Sabrina
dc.contributor.authorFlorent, Isabelle
dc.contributor.authorKabasa, John D
dc.date.accessioned2021-12-13T13:07:58Z
dc.date.available2021-12-13T13:07:58Z
dc.date.issued2014
dc.description.abstractNeoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the isolation of nine cycloartane triterpenes (1–9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9, 10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-Oacetyl- 26-deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13). The chemical structures of the compounds were established mainly through a combination of spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven out of 13 compounds exhibited good antiplasmodial activity with IC50 of 65 lg/ml with two compounds exhibiting low cytotoxicity and five compounds having significant cytotoxicity.en_US
dc.identifier.citationNamukobe, J., Kiremire, B. T., Byamukama, R., Kasenene, J. M., Dumontet, V., Guéritte, F., ... & Kabasa, J. D. (2014). Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L. Phytochemistry, 102, 189-196.http://dx.doi.org/10.1016/j.phytochem.2014.02.005en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.phytochem.2014.02.005
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/439
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectNeoboutonia macrocalyxen_US
dc.subjectEuphorbaceaeen_US
dc.subjectAntiplasmodial activityen_US
dc.subjectCytotoxicityen_US
dc.subjectCycloartane triterpenoidsen_US
dc.subjectPhenanthreneen_US
dc.subjectSteroiden_US
dc.titleCycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.en_US
dc.typeArticleen_US
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