Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Neoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park
in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the
isolation of nine cycloartane triterpenes (1–9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9,
10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-Oacetyl-
26-deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13).
The chemical structures of the compounds were established mainly through a combination of
spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against
the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against
the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven
out of 13 compounds exhibited good antiplasmodial activity with IC50 of 65 lg/ml with two compounds
exhibiting low cytotoxicity and five compounds having significant cytotoxicity.
Description
Keywords
Neoboutonia macrocalyx, Euphorbaceae, Antiplasmodial activity, Cytotoxicity, Cycloartane triterpenoids, Phenanthrene, Steroid
Citation
Namukobe, J., Kiremire, B. T., Byamukama, R., Kasenene, J. M., Dumontet, V., Guéritte, F., ... & Kabasa, J. D. (2014). Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L. Phytochemistry, 102, 189-196.http://dx.doi.org/10.1016/j.phytochem.2014.02.005