Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala

Simple item page
dc.contributor.authorOdongo, Charles Okot
dc.contributor.authorOdida, Michael
dc.contributor.authorWabinga, Henry
dc.contributor.authorObua, Celestino
dc.contributor.authorByamugisha, Josaphat
dc.date.accessioned2023-02-27T20:17:30Z
dc.date.available2023-02-27T20:17:30Z
dc.date.issued2016
dc.description.abstractIntermittent preventive treatment of malaria in pregnancy with sulphadoxine-pyrimethamine (SP-IPTp) is widely used to reduce the incidence of adverse pregnancy outcomes. As a monitor for continued effectiveness of this intervention amidst SP resistance, we aimed to assess malaria burden among pregnant women who use or do not use SP-IPTp. In a descriptive cohort study at Mulago Hospital, Kampala, 87 women who received two supervised doses of SP-IPTp were followed up until delivery. Controls were pregnant women presenting in early labour without history of SP-IPTp. Histopathological investigation for placental malaria (PM) was performed using the Bulmer classification criterion. Thirty-eight of the 87 women returned for delivery and 33 placentas were successfully collected and processed along with 33 placentas from SP nonusers. Overall, 12% (4/33) of the users had evidence of PM compared to 48% (16/33) of nonusers. Among nonusers, 17/33, 8/33, 2/33, and 6/33 had no placental infection, active infection, active-chronic infection, and past-chronic infection, respectively. Among users, respective proportions were 29/33, 2/33, 0/33, and 2/33. No difference in birth weights was apparent between the two groups, probably due to a higher proportion of infections occurring later in pregnancy. Histological evidence here suggests that SP continues to offer substantial benefit as IPTp.en_US
dc.identifier.citationOdongo, C. O., Odida, M., Wabinga, H., Obua, C., & Byamugisha, J. (2016). Burden of placental malaria among pregnant women who use or do not use intermittent preventive treatment at Mulago Hospital, Kampala. Malaria Research and Treatment, 2016.http://dx.doi.org/10.1155/2016/1839795en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8010
dc.language.isoenen_US
dc.publisherMalaria Research and Treatmenten_US
dc.subjectPlacental Malariaen_US
dc.subjectPregnant Womenen_US
dc.subjectIntermittent Preventive Treatmenten_US
dc.titleBurden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampalaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala.pdf
Size:
1.22 MB
Format:
Adobe Portable Document Format
Description:
Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences