Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Malaria Research and Treatment
Abstract
Intermittent preventive treatment of malaria in pregnancy with sulphadoxine-pyrimethamine (SP-IPTp) is widely used to reduce
the incidence of adverse pregnancy outcomes. As a monitor for continued effectiveness of this intervention amidst SP resistance,
we aimed to assess malaria burden among pregnant women who use or do not use SP-IPTp. In a descriptive cohort study at
Mulago Hospital, Kampala, 87 women who received two supervised doses of SP-IPTp were followed up until delivery. Controls
were pregnant women presenting in early labour without history of SP-IPTp. Histopathological investigation for placental malaria
(PM) was performed using the Bulmer classification criterion. Thirty-eight of the 87 women returned for delivery and 33 placentas
were successfully collected and processed along with 33 placentas from SP nonusers. Overall, 12% (4/33) of the users had evidence of PM compared to 48% (16/33) of nonusers. Among nonusers, 17/33, 8/33, 2/33, and 6/33 had no placental infection, active infection, active-chronic infection, and past-chronic infection, respectively. Among users, respective proportions were 29/33, 2/33, 0/33, and 2/33. No difference in birth weights was apparent between the two groups, probably due to a higher proportion of infections occurring later in pregnancy. Histological evidence here suggests that SP continues to offer substantial benefit as IPTp.
Description
Keywords
Placental Malaria, Pregnant Women, Intermittent Preventive Treatment
Citation
Odongo, C. O., Odida, M., Wabinga, H., Obua, C., & Byamugisha, J. (2016). Burden of placental malaria among pregnant women who use or do not use intermittent preventive treatment at Mulago Hospital, Kampala. Malaria Research and Treatment, 2016.http://dx.doi.org/10.1155/2016/1839795