Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats

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dc.contributor.authorKasolo, Josephine N.
dc.contributor.authorNamaganda, Agnes
dc.contributor.authorNfambi, Joshua
dc.contributor.authorKimuli, Ivan
dc.contributor.authorMuwonge, Haruna
dc.contributor.authorOkullo, Isaac
dc.date.accessioned2022-05-10T11:32:18Z
dc.date.available2022-05-10T11:32:18Z
dc.date.issued2019
dc.description.abstractDiabetes being one of the commonest non-communicable diseases worldwide has no cure. The available hypoglycemic drugs are costly, and have associated long-term side effects. M. oleifera leaves are used in many countries in Africa and Asia to treat diabetes. The study compared the hyperglycemic control of M. oleifera leaves aqueous extract and Glibenclamide tablet in alloxan monohydrate induced diabetic rats. Methods: Twenty-four female Wistar albino rats, made diabetic using alloxan monohydrate, received either M. oleifera extract, glibenclamide or distilled water were delivered intragastric. The mean body weight and mean fasting blood sugar were measured over a period of 28 days. Results: Rats that received distilled water had a mean fasting blood sugar of 329.3+44.9 mg/dl at the beginning, which increased to 448.0+189.9 mg/dl on day 14; all the rats were dead by day 21. The rats that received M. oleifera had blood sugar 443.4+134.7 mg/dl at the beginning, dropped to 166.5+162.79 mg/dl by day 14, and to 88.7+41.0 mg/dl by day 28. Rats that received glibenclamide had blood sugar 517.6+139.3mg/dl at the beginning, dropped to 209.0+201.9 mg/dl on day 14, and to 89.7+42.85 mg/dl on day 28. The blood sugar of the M. oleifera and glibenclamide groups reached normal level by day 21 and remained within the normal range up to day 28. Conclusion: Moringa oleifera leaves aqueous extract has similar pattern to glibenclamide tablet in causing hypoglycemia to alloxan monohydrate induced diabetic rats.en_US
dc.identifier.citationKasolo, J. N., Namaganda, A., Nfambi, J., Kimuli, I., Muwonge, H., & Okullo, I. (2019). Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats. Asian Journal of Research in Medical and Pharmaceutical Sciences, 7, 1-9. DOI: 10.9734/AJRIMPS/2019/v7i130112 Editor(s):en_US
dc.identifier.issn2457-0745
dc.identifier.other10.9734/AJRIMPS/2019/v7i130112
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3214
dc.language.isoenen_US
dc.publisherAsian Journal of Research in Medical and Pharmaceutical Sciencesen_US
dc.subjectM. oleiferaen_US
dc.subjectAlloxan induced diabetesen_US
dc.subjectGlibenclamideen_US
dc.subjectHypoglycemiaen_US
dc.subjectWistar ratsen_US
dc.titleComparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Ratsen_US
dc.typeArticleen_US
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