Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Asian Journal of Research in Medical and Pharmaceutical Sciences
Abstract
Diabetes being one of the commonest non-communicable diseases worldwide has
no cure. The available hypoglycemic drugs are costly, and have associated long-term side effects.
M. oleifera leaves are used in many countries in Africa and Asia to treat diabetes. The study
compared the hyperglycemic control of M. oleifera leaves aqueous extract and Glibenclamide
tablet in alloxan monohydrate induced diabetic rats.
Methods: Twenty-four female Wistar albino rats, made diabetic using alloxan monohydrate,
received either M. oleifera extract, glibenclamide or distilled water were delivered intragastric. The
mean body weight and mean fasting blood sugar were measured over a period of 28 days. Results: Rats that received distilled water had a mean fasting blood sugar of 329.3+44.9 mg/dl at
the beginning, which increased to 448.0+189.9 mg/dl on day 14; all the rats were dead by day 21.
The rats that received M. oleifera had blood sugar 443.4+134.7 mg/dl at the beginning, dropped to
166.5+162.79 mg/dl by day 14, and to 88.7+41.0 mg/dl by day 28. Rats that received
glibenclamide had blood sugar 517.6+139.3mg/dl at the beginning, dropped to 209.0+201.9 mg/dl
on day 14, and to 89.7+42.85 mg/dl on day 28. The blood sugar of the M. oleifera and
glibenclamide groups reached normal level by day 21 and remained within the normal range up to
day 28. Conclusion: Moringa oleifera leaves aqueous extract has similar pattern to glibenclamide
tablet in causing hypoglycemia to alloxan monohydrate induced diabetic rats.
Description
Keywords
M. oleifera, Alloxan induced diabetes, Glibenclamide, Hypoglycemia, Wistar rats
Citation
Kasolo, J. N., Namaganda, A., Nfambi, J., Kimuli, I., Muwonge, H., & Okullo, I. (2019). Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats. Asian Journal of Research in Medical and Pharmaceutical Sciences, 7, 1-9. DOI: 10.9734/AJRIMPS/2019/v7i130112 Editor(s):