Effect of Human Immunodeficiency Virus (HIV) Type 1 Envelope Subtypes A and D on Disease Progression in a Large Cohort of HIV-1–Positive Persons in Uganda

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dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorFrench, Neil
dc.contributor.authorMahe, Cedric
dc.contributor.authorYirrell, David
dc.contributor.authorWatera, Christine
dc.contributor.authorLyagoba, Fred
dc.contributor.authorNakiyingi, Jessica
dc.contributor.authorRutebemberwa, Alleluiah
dc.contributor.authorMorgan, Dilys
dc.contributor.authorWeber, Jonathan
dc.contributor.authorGilks, Charles
dc.contributor.authorWhitworth, Jimmy
dc.date.accessioned2022-01-03T18:10:15Z
dc.date.available2022-01-03T18:10:15Z
dc.date.issued2002
dc.description.abstractThe effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07–1.56; P ¼ .009) and with a lower CD4 cell count during follow-up (P ¼ .001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype Aen_US
dc.identifier.citationKaleebu, P., French, N., Mahe, C., Yirrell, D., Watera, C., Lyagoba, F., ... & Whitworth, J. (2002). Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1—positive persons in Uganda. The Journal of infectious diseases, 185(9), 1244-1250.en_US
dc.identifier.urihttps://doi.org/10.1086/340130
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/983
dc.language.isoenen_US
dc.publisherThe Journal of Infectious Diseasesen_US
dc.relation.ispartofseriesThe Journal of Infectious Diseases;
dc.subjectHIVen_US
dc.subjectAfricaen_US
dc.subjectCD4 count dterminationen_US
dc.subjectDisease progressionen_US
dc.subjectFollow upen_US
dc.subjectHIV-1en_US
dc.subjectsequence analysisen_US
dc.titleEffect of Human Immunodeficiency Virus (HIV) Type 1 Envelope Subtypes A and D on Disease Progression in a Large Cohort of HIV-1–Positive Persons in Ugandaen_US
dc.typeArticleen_US
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