Effect of Human Immunodeficiency Virus (HIV) Type 1 Envelope Subtypes A and D on Disease Progression in a Large Cohort of HIV-1–Positive Persons in Uganda
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Date
2002
Authors
Kaleebu, Pontiano
French, Neil
Mahe, Cedric
Yirrell, David
Watera, Christine
Lyagoba, Fred
Nakiyingi, Jessica
Rutebemberwa, Alleluiah
Morgan, Dilys
Weber, Jonathan
Journal Title
Journal ISSN
Volume Title
Publisher
The Journal of Infectious Diseases
Abstract
The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07–1.56; P ¼ .009) and with a lower CD4 cell count during follow-up (P ¼ .001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A
Description
Keywords
HIV, Africa, CD4 count dtermination, Disease progression, Follow up, HIV-1, sequence analysis
Citation
Kaleebu, P., French, N., Mahe, C., Yirrell, D., Watera, C., Lyagoba, F., ... & Whitworth, J. (2002). Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1—positive persons in Uganda. The Journal of infectious diseases, 185(9), 1244-1250.