Toxicity of four herbs used in erectile dysfunction;Mondia whiteii,Cola acuminata,Urtica massaica, and Tarenna graveolensin male rats

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dc.contributor.authorOloro, Joseph
dc.contributor.authorTanayen Kihdze, Julius
dc.contributor.authorKatusiime, Barbra
dc.contributor.authorImanirampa, Lawrence
dc.contributor.authorWaako, Paul
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorAgaba Ganafa, Amon
dc.date.accessioned2021-12-13T07:04:45Z
dc.date.available2021-12-13T07:04:45Z
dc.date.issued2015
dc.description.abstractIn Sub-Saharan Africa, herbal medicines are commonly used for prevention or treatment of illnesses, including erectile dysfunction. Contemporary medicines used to manage erectile dysfunction are not only inaccessible to local populations, but also impose significant out-of-pocket expenditure on patients. Herbal medicines offer alternatives for alleviating erectile dysfunction, which has clinical, psychological and societal consequences. Regardless, there are increasing concerns about the safety and/or toxicity of herbal medicines. In this study, the toxicity of aqueous extracts of four herbs, commonly used in south-western Uganda, to manage erectile dysfunction, was investigated. Acute and sub-chronic toxicity studies were conducted following the Organization for Economic Cooperation and Development (OECD) guidelines for toxicity study. All four plants extracts were found safe at single dose exposure up to the limit dose of 5000 mg/kg. Extracts of Cola acuminate reduced the weights of the experimental animals, Tarenna graveolens and Cola acuminata indicated low level liver toxicity and Tarenna graveolens, Cola acuminata and Urtica massaica indicated low level renal toxicity following multiple exposures for 90 days. Three of the four herbs studied have shown low level toxicity on multiple exposure for 90 days.en_US
dc.identifier.citationJoseph, O., Kihdze, T. J., Katusiime, B., Imanirampa, L., Waako, P., Bajunirwe, F., & Ganafa, A. A. (2015). Toxicity of four herbs used in erectile dysfunction; Mondia whiteii, Cola acuminata, Urtica massaica, and Tarenna graveolensin male rats. African Journal of Pharmacy and Pharmacology, 9(30), 756-763.DOI: 10.5897/AJPP2015.4299en_US
dc.identifier.issn1996-0816
dc.identifier.other10.5897/AJPP2015.4299
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/384
dc.language.isoenen_US
dc.publisherAfrican Journal of Pharmacy and Pharmacologyen_US
dc.subjectToxicityen_US
dc.subjectMondia whiteiien_US
dc.subjectCola acuminataen_US
dc.subjectUrtica massaicaen_US
dc.subjectTarenna graveolensen_US
dc.titleToxicity of four herbs used in erectile dysfunction;Mondia whiteii,Cola acuminata,Urtica massaica, and Tarenna graveolensin male ratsen_US
dc.typeArticleen_US
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