Toxicity of four herbs used in erectile dysfunction;Mondia whiteii,Cola acuminata,Urtica massaica, and Tarenna graveolensin male rats
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
African Journal of Pharmacy and Pharmacology
Abstract
In Sub-Saharan Africa, herbal medicines are commonly used for prevention or treatment of illnesses,
including erectile dysfunction. Contemporary medicines used to manage erectile dysfunction are not
only inaccessible to local populations, but also impose significant out-of-pocket expenditure on
patients. Herbal medicines offer alternatives for alleviating erectile dysfunction, which has clinical,
psychological and societal consequences. Regardless, there are increasing concerns about the safety
and/or toxicity of herbal medicines. In this study, the toxicity of aqueous extracts of four herbs,
commonly used in south-western Uganda, to manage erectile dysfunction, was investigated. Acute and
sub-chronic toxicity studies were conducted following the Organization for Economic Cooperation and
Development (OECD) guidelines for toxicity study. All four plants extracts were found safe at single
dose exposure up to the limit dose of 5000 mg/kg. Extracts of Cola acuminate reduced the weights of
the experimental animals, Tarenna graveolens and Cola acuminata indicated low level liver toxicity and
Tarenna graveolens, Cola acuminata and Urtica massaica indicated low level renal toxicity following
multiple exposures for 90 days. Three of the four herbs studied have shown low level toxicity on
multiple exposure for 90 days.
Description
Keywords
Toxicity, Mondia whiteii, Cola acuminata, Urtica massaica, Tarenna graveolens
Citation
Joseph, O., Kihdze, T. J., Katusiime, B., Imanirampa, L., Waako, P., Bajunirwe, F., & Ganafa, A. A. (2015). Toxicity of four herbs used in erectile dysfunction; Mondia whiteii, Cola acuminata, Urtica massaica, and Tarenna graveolensin male rats. African Journal of Pharmacy and Pharmacology, 9(30), 756-763.DOI: 10.5897/AJPP2015.4299