The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette–Gue´rin immunization

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dc.contributor.authorMawa, Patrice A.
dc.contributor.authorNkurunungi, Gyaviira
dc.contributor.authorEgesa, Moses
dc.contributor.authorWebb, Emily L.
dc.contributor.authorSmith, Steven G.
dc.contributor.authorKizindo, Robert
dc.contributor.authorAkello, Mirriam
dc.contributor.authorLule, Swaib A.
dc.contributor.authorMuwanga, Moses
dc.contributor.authorDockrell, Hazel M.
dc.contributor.authorCose, Stephen
dc.contributor.authorElliott, Alison M.
dc.date.accessioned2021-12-15T06:56:56Z
dc.date.available2021-12-15T06:56:56Z
dc.date.issued2015
dc.description.abstractBacille Calmette–Gue´rin (BCG) immunization provides variable protection against tuberculosis. Prenatal antigen exposure may have lifelong effects on responses to related antigens and pathogens. We therefore hypothesized that maternal latent Mycobacterium tuberculosis infection (LTBI) influences infant responses to BCG immunization at birth. We measured antibody (n ¼ 53) and cellular (n ¼ 31) responses to M. tuberculosis purified protein derivative (PPD) in infants of mothers with and without LTBI, in cord blood and at one and six weeks after BCG. The concentrations of PPD-specific antibodies declined between birth (median [interquartile range (IQR)]) 5600 ng ml21 [3300–11 050] in cord blood) and sixweeks (0.00 ng ml21 [0–288]). Frequencies of PPD-specific IFN-g-expressing CD4þT cells increased at one week and declined between one and six weeks ( p ¼ 0.031). Frequencies of IL-2- and TNF-a-expressing PPD-specific CD4þT cells increased between one and six weeks ( p ¼ 0.019, p ¼ 0.009, respectively). At one week, the frequency of PPD-specific CD4þT cells expressing any of the three cytokines, combined, was lower among infants of mothers with LTBI, in crude analyses ( p ¼ 0.002) and after adjusting for confounders (mean difference, 95% CI 20.041% (20.082, 20.001)). In conclusion, maternal LTBI was associated with lower infant anti-mycobacterial T-cell responses immediately following BCGimmunization. These findings are being explored further in a larger study.en_US
dc.identifier.citationMawa, P. A., Nkurunungi, G., Egesa, M., Webb, E. L., Smith, S. G., Kizindo, R., ... & Elliott, A. M. (2015). The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette–Guérin immunization. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1671), 20140137.http://dx.doi.org/10.1098/rstb.2014.0137en_US
dc.identifier.urihttp://dx.doi.org/10.1098/rstb.2014.0137
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/525
dc.language.isoenen_US
dc.publisherPhilosophical Transactions of the Royal Society B: Biological Sciencesen_US
dc.subjectMaternal infectionen_US
dc.subjectMycobacteriaen_US
dc.subjectBacille Calmette–Gue´rinen_US
dc.subjectPurified protein derivativeen_US
dc.subjectTuberculosisen_US
dc.subjectImmunizationen_US
dc.titleThe impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette–Gue´rin immunizationen_US
dc.typeArticleen_US
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