Antimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr.

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dc.contributor.authorOloya, Benson
dc.contributor.authorNamukobe, Jane
dc.contributor.authorHeydenreich, Matthias
dc.contributor.authorSsengooba, Willy
dc.contributor.authorSchmidt, Bernd
dc.contributor.authorByamukama, Robert
dc.date.accessioned2021-12-13T12:30:31Z
dc.date.available2021-12-13T12:30:31Z
dc.date.issued2021
dc.description.abstractZanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), (S)-marmesinin (5), and hesperidin (6) were isolated from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial activity. The extract exhibited moderate activity against the susceptible (H37Rv) TB strain, but weak activity against the multidrug resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 μg/mL, respectively. Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H37Rv) TB strain (MIC 6 μg/mL), but moderate activity against the MDR-TB strain (MIC 12.2 μg/mL). Compounds 2, 5, 6, and 1 showed moderate activitiesagainst the susceptible (H37Rv) strain (MIC 12.2-98.0 μg/mL) and moderate to weak activities against theMDR-TB strain (MIC24.4-195.0 μg/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugsen_US
dc.identifier.citationOloya, B., Namukobe, J., Heydenreich, M., Ssengooba, W., Schmidt, B., & Byamukama, R. (2021). Antimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr. Natural Product Communications, 16(8), 1934578X211035851.DOI: 10.1177/1934578X211035851en_US
dc.identifier.other10.1177/1934578X211035851
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/429
dc.language.isoenen_US
dc.publisherNatural Product Communicationsen_US
dc.subjectTuberculosisen_US
dc.subjectZanthoxylum leprieuriien_US
dc.subjectAntimycobacterial activityen_US
dc.subjectTrans-fagaramideen_US
dc.subjectAlkaloiden_US
dc.titleAntimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr.en_US
dc.typeArticleen_US
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