Antimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr.
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Natural Product Communications
Abstract
Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related
infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), (S)-marmesinin (5), and hesperidin (6) were isolated
from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques
and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial
activity. The extract exhibited moderate activity against the susceptible (H37Rv) TB strain, but weak activity against the multidrug
resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 μg/mL, respectively.
Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H37Rv) TB strain (MIC
6 μg/mL), but moderate activity against the MDR-TB strain (MIC 12.2 μg/mL). Compounds 2, 5, 6, and 1 showed moderate activitiesagainst the susceptible (H37Rv) strain (MIC 12.2-98.0 μg/mL) and moderate to weak activities against theMDR-TB strain (MIC24.4-195.0 μg/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugs
Description
Keywords
Tuberculosis, Zanthoxylum leprieurii, Antimycobacterial activity, Trans-fagaramide, Alkaloid
Citation
Oloya, B., Namukobe, J., Heydenreich, M., Ssengooba, W., Schmidt, B., & Byamukama, R. (2021). Antimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr. Natural Product Communications, 16(8), 1934578X211035851.DOI: 10.1177/1934578X211035851