Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease

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dc.contributor.authorWampande, Eddie M.
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorDebanne, SaraM
dc.contributor.authorAsiimwe, Benon B.
dc.contributor.authorNsereko, Mary
dc.contributor.authorMayanja, Harriet
dc.contributor.authorEisenach, Kathleen
dc.contributor.authorKaplan, Gilla
dc.contributor.authorBoom, Henry W.
dc.contributor.authorGagneux, Sebastien
dc.contributor.authorJoloba, Moses L.
dc.date.accessioned2022-01-30T21:48:57Z
dc.date.available2022-01-30T21:48:57Z
dc.date.issued2013
dc.description.abstractPrevious studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala. A total of 1,746 MTB clinical isolates collected from1992-2009 in a household contact study were genotyped. Genotyping was performed using Single Nucleotide Polymorphic (SNP) markers specific for the MTB Uganda family, other Lineage 4 strains, and Lineage 3, respectively. Out of 1,746 isolates, 1,213 were from patients with detailed clinical data. These data were used to seek associations between MTB lineage/sub-lineage and patient phenotypes.en_US
dc.identifier.citationWampande et al.: Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease. BMC Infectious Diseases 2013 13:484. doi:10.1186/1471-2334-13-484en_US
dc.identifier.otherdoi:10.1186/1471-2334-13-484
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1646
dc.language.isoenen_US
dc.publisherBMC Infectious Diseasesen_US
dc.subjectMycobacterium tuberculosis complexen_US
dc.subjectLineageen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subjectMycobacteriaen_US
dc.subjectStrain familyen_US
dc.subjectCavitationen_US
dc.subjectVirulenceen_US
dc.subjectEpidemiologyen_US
dc.subjectEvolutionen_US
dc.titleLong-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary diseaseen_US
dc.typeArticleen_US
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