Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease
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Date
2013
Authors
Wampande, Eddie M.
Mupere, Ezekiel
Debanne, SaraM
Asiimwe, Benon B.
Nsereko, Mary
Mayanja, Harriet
Eisenach, Kathleen
Kaplan, Gilla
Boom, Henry W.
Gagneux, Sebastien
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Infectious Diseases
Abstract
Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala.
A total of 1,746 MTB clinical isolates collected from1992-2009 in a household contact study were genotyped. Genotyping was performed using Single Nucleotide Polymorphic (SNP) markers specific for the MTB Uganda family, other Lineage 4 strains, and Lineage 3, respectively. Out of 1,746 isolates, 1,213 were from patients with detailed clinical data. These data were used to seek associations between MTB lineage/sub-lineage and patient phenotypes.
Description
Keywords
Mycobacterium tuberculosis complex, Lineage, Single nucleotide polymorphism, Mycobacteria, Strain family, Cavitation, Virulence, Epidemiology, Evolution
Citation
Wampande et al.: Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease. BMC Infectious Diseases 2013 13:484. doi:10.1186/1471-2334-13-484