Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha

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dc.contributor.authorNdibalema, Angelamellisy Revelian
dc.contributor.authorKabuye, Deo
dc.contributor.authorWen, Si
dc.contributor.authorLi, Lulu
dc.contributor.authorFan, Qiuling
dc.date.accessioned2023-03-29T19:57:34Z
dc.date.available2023-03-29T19:57:34Z
dc.date.issued2020
dc.description.abstractEvidence from both animal and human studies clearly supports the renal beneficial effects of empagliflozin (emp), a sodium glucose co-transporter 2 (SGLT2) inhibitor, but the mechanism in which it exerts its effect is not well understood. In this study, we investigated the capability of emp on reducing hyperglycemia-induced renal proximal tubular epithelial cells injury and we evaluated if the renoprotective effect of emp associates with hypoxia-inducible factor-1α (HIF-1α).en_US
dc.identifier.citationNdibalema, A. R., Kabuye, D., Wen, S., Li, L., Li, X., & Fan, Q. (2020). Empagliflozin protects against proximal renal tubular cell injury induced by high glucose via regulation of hypoxia-inducible factor 1-alpha. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 1953.https://doi.org/10.2147%2FDMSO.S243170en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8329
dc.language.isoenen_US
dc.publisherTargets and Therapyen_US
dc.subjectHypoxia-Inducible Factor 1-Alphaen_US
dc.subjectHigh Glucoseen_US
dc.subjectProximal Renal Tubular Cell Injuryen_US
dc.titleEmpagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alphaen_US
dc.typeArticleen_US

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