Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha

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Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.pdf (6.2 MB)
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.pdf (6.2 MB)
Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Targets and Therapy
Abstract
Evidence from both animal and human studies clearly supports the renal beneficial effects of empagliflozin (emp), a sodium glucose co-transporter 2 (SGLT2) inhibitor, but the mechanism in which it exerts its effect is not well understood. In this study, we investigated the capability of emp on reducing hyperglycemia-induced renal proximal tubular epithelial cells injury and we evaluated if the renoprotective effect of emp associates with hypoxia-inducible factor-1α (HIF-1α).
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Keywords
Hypoxia-Inducible Factor 1-Alpha, High Glucose, Proximal Renal Tubular Cell Injury
Citation
Ndibalema, A. R., Kabuye, D., Wen, S., Li, L., Li, X., & Fan, Q. (2020). Empagliflozin protects against proximal renal tubular cell injury induced by high glucose via regulation of hypoxia-inducible factor 1-alpha. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 1953.https://doi.org/10.2147%2FDMSO.S243170
URI
https://nru.uncst.go.ug/handle/123456789/8329
Collections
Medical and Health Sciences