Force‑of‑infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends

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dc.contributor.authorDixon, Matthew A.
dc.contributor.authorWinskill, Peter
dc.contributor.authorHarrison, Wendy E.
dc.contributor.authorWhittaker, Charles
dc.contributor.authorSchmidt, Veronika
dc.contributor.authorSarti, Elsa
dc.contributor.authorBawm, Saw
dc.contributor.authorDione, Michel M.
dc.contributor.authorThomas, Lian F.
dc.contributor.authorWalker, Martin
dc.contributor.authorBasáñez, Maria‑Gloria
dc.date.accessioned2022-08-21T13:43:15Z
dc.date.available2022-08-21T13:43:15Z
dc.date.issued2020
dc.description.abstractThe World Health Organization (WHO) called, in 2012, for a validated strategy towards Taenia solium taeniasis/cysticercosis control and elimination. Estimating pig force-of-infection (FoI, the average rate at which susceptible pigs become infected) across geographical settings will help understand local epidemiology and inform effective intervention design. Porcine cysticercosis (PCC) ageprevalence data (from 15 studies in Latin America, Africa and Asia) were identified through systematic review. Catalytic models were fitted to the data using Bayesian methods, incorporating uncertainty in diagnostic performance, to estimate rates of antibody seroconversion, viable metacestode acquisition, and seroreversion/infection loss. There was evidence of antibody seroreversion across 5 studies, and of infection loss in 6 studies measured by antigen or necropsy, indicating transient serological responses and natural resolution of infection. Concerted efforts should be made to collect robust data using improved diagnostics to better understand geographical heterogeneities in T. solium transmission to support post-2020 WHO targets.en_US
dc.identifier.citationDixon, M. A., Winskill, P., Harrison, W. E., Whittaker, C., Schmidt, V., Sarti, E., ... & Basáñez, M. G. (2020). Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends. Scientific reports, 10(1), 1-14.Dixon, M. A., Winskill, P., Harrison, W. E., Whittaker, C., Schmidt, V., Sarti, E., ... & Basáñez, M. G. (2020). Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends. Scientific reports, 10(1), 1-14. https://doi.org/10.1038/s41598-020-74007-xen_US
dc.identifier.urihttps://doi.org/10.1038/s41598-020-74007-x
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4345
dc.language.isoenen_US
dc.publisherScientific reportsen_US
dc.subjectTaenia solium porcine cysticercosisen_US
dc.subjectModelling analysisen_US
dc.subjectGlobal incidenceen_US
dc.subjectPrevalence trendsen_US
dc.titleForce‑of‑infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trendsen_US
dc.typeArticleen_US
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