Genetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis

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dc.contributor.authorEchodu, Richard
dc.contributor.authorSistrom, Mark
dc.contributor.authorHyseni, Chaz
dc.contributor.authorEnyaru, John
dc.contributor.authorOkedi, Loyce
dc.contributor.authorAksoy, Serap
dc.contributor.authorCaccone, Adalgisa
dc.date.accessioned2022-11-17T11:18:48Z
dc.date.available2022-11-17T11:18:48Z
dc.date.issued2013
dc.description.abstractTsetse flies (Glossina spp.) are the sole vectors of Trypanosoma brucei—the agent of human (HAT) and animal (AAT) trypanosomiasis. Glossina fuscipes fuscipes (Gff ) is the main vector species in Uganda—the only country where the two forms of HAT disease (rhodesiense and gambiense) occur, with gambiense limited to the northwest. Gff populations cluster in three genetically distinct groups in northern, southern, and western Uganda, respectively, with a contact zone present in central Uganda. Understanding the dynamics of this contact zone is epidemiologically important as the merger of the two diseases is amajor health concern.We used mitochondrial and microsatellite DNA data fromGff samples in the contact zone to understand its spatial extent and temporal stability.We show that this zone is relatively narrow, extending through central Uganda alongmajor rivers with south to north introgression but displaying no sex-biased dispersal. Lack of obvious vicariant barriers suggests that either environmental conditions or reciprocal competitive exclusion could explain the patterns of genetic differentiation observed. Lack of admixture between northern and southern populations may prevent the sympatry of the two forms of HAT disease, although continued control efforts are needed to prevent the recolonization of tsetse-free regions by neighboring populations.en_US
dc.identifier.citationEchodu, R., Sistrom, M., Hyseni, C., Enyaru, J., Okedi, L., Aksoy, S., & Caccone, A. (2013). Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for human African trypanosomiasis. BioMed research international , 2013. http://dx.doi.org/10.1155/2013/614721en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2013/614721
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/5323
dc.language.isoenen_US
dc.publisherBioMed research internationalen_US
dc.subjectGlossina fuscipesen_US
dc.subjectLake Kyoga Regionen_US
dc.subjectHuman African Trypanosomiasisen_US
dc.subjectUgandaen_US
dc.titleGenetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasisen_US
dc.typeArticleen_US
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