High prevalence of Pfmdr‑1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda

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dc.contributor.authorAchol, Emmanuel
dc.contributor.authorOchaya, Stephen
dc.contributor.authorMalinga, Geoffrey M.
dc.contributor.authorEdema, Hillary
dc.contributor.authorEchodu, Richard
dc.date.accessioned2022-11-17T11:55:22Z
dc.date.available2022-11-17T11:55:22Z
dc.date.issued2019
dc.description.abstractTo determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda. Results: Overall, 92.3% (n = 48/52) and 90% (n = 45/50) of the parasites detected carried the wild type alleles 1246D and N86, respectively. Only 7.7% (n = 4/52) and 10% (n = 5/50) of these P. falciparum isolates carried the Pfmdr-1 mutant alleles 1246Y and 86Y, respectively. Our results show high prevalence of wild type alleles N86 and D1246 in P. falciparum isolates from Lira Regional Referral Hospital, which could translate to a decreased sensitivity to artemetherlumefantrine. Continued monitoring of prevalence of single nucleotide polymorphisms is warranted to timely inform malaria treatment policies and guidelines.en_US
dc.identifier.citationAchol, E., Ochaya, S., Malinga, GM, Edema, H., & Echodu, R. (2019). High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda. BMC Research Notes , 12 (1), 1-4. https://doi.org/10.1186/s13104-019-4269-1en_US
dc.identifier.urihttps://doi.org/10.1186/s13104-019-4269-1
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/5329
dc.language.isoenen_US
dc.publisherBMC Research Notesen_US
dc.subjectMalariaen_US
dc.subjectPfmdr-1en_US
dc.subjectMutationen_US
dc.subjectDrug resistanceen_US
dc.subjectGenotypesen_US
dc.subjectPrevalenceen_US
dc.subjectSNPsen_US
dc.subjectResistanceen_US
dc.titleHigh prevalence of Pfmdr‑1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Ugandaen_US
dc.typeArticleen_US
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