High prevalence of Pfmdr‑1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Research Notes
Abstract
To determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and
D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda.
Results: Overall, 92.3% (n = 48/52) and 90% (n = 45/50) of the parasites detected carried the wild type alleles 1246D
and N86, respectively. Only 7.7% (n = 4/52) and 10% (n = 5/50) of these P. falciparum isolates carried the Pfmdr-1
mutant alleles 1246Y and 86Y, respectively. Our results show high prevalence of wild type alleles N86 and D1246 in P.
falciparum isolates from Lira Regional Referral Hospital, which could translate to a decreased sensitivity to artemetherlumefantrine.
Continued monitoring of prevalence of single nucleotide polymorphisms is warranted to timely inform
malaria treatment policies and guidelines.
Description
Keywords
Malaria, Pfmdr-1, Mutation, Drug resistance, Genotypes, Prevalence, SNPs, Resistance
Citation
Achol, E., Ochaya, S., Malinga, GM, Edema, H., & Echodu, R. (2019). High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda. BMC Research Notes , 12 (1), 1-4. https://doi.org/10.1186/s13104-019-4269-1