Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda

Simple item page
dc.contributor.authorTushabe, Phionah
dc.contributor.authorHoward, Wayne
dc.contributor.authorBwogi, Josephine
dc.contributor.authorBirungi, Molly
dc.contributor.authorEliku, James P.
dc.contributor.authorKakooza, Proscovia
dc.contributor.authorBukenya, Henry
dc.contributor.authorNamuwulya, Prossy
dc.contributor.authorGaizi, Joseph
dc.contributor.authorTibanagwa, Mayi
dc.contributor.authorKabaliisa, Theopista
dc.contributor.authorMulindwa, Julius
dc.contributor.authorMuhanguzi, Dennis
dc.contributor.authorSuchard, Melinda
dc.contributor.authorGumede, Nicksy
dc.contributor.authorBakamutumaho, Barnabas
dc.date.accessioned2022-08-05T15:55:30Z
dc.date.available2022-08-05T15:55:30Z
dc.date.issued2021
dc.description.abstractEnteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non‐polio enteroviruses (NPEVs). Specific NPEVs have been described in polio‐like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% were Enterovirus B and 9% were Enterovirus A species. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV‐B5), CV‐B6, E21, and EV‐B69 were only seen in patients with residual paralysis. Analyses of the EV‐A71 sequence indicated a unique genogroup.en_US
dc.identifier.citationTushabe, P., Howard, W., Bwogi, J., Birungi, M., Eliku, JP, Kakooza, P., ... & Bakamutumaho, B. (2021). Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda. Journal of Medical Virology , 93 (8), 4720-4728. DOI: 10.1002/jmv.26804en_US
dc.identifier.other10.1002/jmv.26804
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4258
dc.language.isoenen_US
dc.publisherJournal of Medical Virologyen_US
dc.subjectAcute flaccid paralysisen_US
dc.subjectNon polio enterovirusesen_US
dc.subjectResidual paralysisen_US
dc.subjectSemi‐nested PCRen_US
dc.titleMolecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Molecular characterization of non‐polio enteroviruses.pdf
Size:
2.05 MB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences