Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda
Loading...
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Medical Virology
Abstract
Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes
including acute flaccid paralysis (AFP). Within the global polio laboratory network,
EVs are categorized either as polioviruses or non‐polio enteroviruses (NPEVs).
Specific NPEVs have been described in polio‐like residual paralytic events in AFP
patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed
and thirty one NPEV types were identified of which 91% were Enterovirus B
and 9% were Enterovirus A species. The NPEVs were distributed across the country
with most patients in the eastern region (41/89; 46.1%). The highest proportion of
patients were children less than 5 years (77/89; 86.5%) and male patients were
more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently
observed and phylogenetic analysis of these sequences revealed high diversity.
Coxsackievirus B5 (CV‐B5), CV‐B6, E21, and EV‐B69 were only seen in patients
with residual paralysis. Analyses of the EV‐A71 sequence indicated a unique
genogroup.
Description
Keywords
Acute flaccid paralysis, Non polio enteroviruses, Residual paralysis, Semi‐nested PCR
Citation
Tushabe, P., Howard, W., Bwogi, J., Birungi, M., Eliku, JP, Kakooza, P., ... & Bakamutumaho, B. (2021). Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda. Journal of Medical Virology , 93 (8), 4720-4728. DOI: 10.1002/jmv.26804