Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adults

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dc.contributor.authorLamorde, Mohammed
dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorBoffito, Marta
dc.contributor.authorNabukeera, Lillian
dc.contributor.authorMayito, Jonathan
dc.contributor.authorOgwal- Okeng, Jasper
dc.contributor.authorTjia, John
dc.contributor.authorBack, David
dc.contributor.authorKhoo, Saye
dc.contributor.authorRyan, Mairin
dc.contributor.authorMerry, Concepta
dc.date.accessioned2022-05-02T23:04:04Z
dc.date.available2022-05-02T23:04:04Z
dc.date.issued2012
dc.description.abstractWe investigated the effect of food on the steady-state pharmacokinetics of lopinavir and ritonavir in 12 Ugandan patients receiving lopinavir co-formulated with ritonavir (LPV/r) tablets using a cross-over design. Intensive pharmacokinetic sampling was performed seven days apart following LPV/r dosing under moderate fat, high fat and fasted meal conditions. Lopinavir and ritonavir concentrations were determined by liquid chromatography and tandem mass spectrometry. Compared to the fasted state, a high fat meal reduced lopinavir and ritonavir area under the curve (AUC) by 14% and 29%, respectively. With a moderate fat meal, AUC for both drugs was similar to the fasted state.en_US
dc.identifier.citationLamorde, M., Byakika-Kibwika, P., Boffito, M., Nabukeera, L., Mayito, J., Ogwal-Okeng, J., ... & Merry, C. (2012). Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adults. Journal of acquired immune deficiency syndromes (1999), 60(3). doi:10.1097/QAI.0b013e3182567a35.en_US
dc.identifier.other10.1097/QAI.0b013e3182567a35.
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3181
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectSteady-state pharmacokineticsen_US
dc.subjectLopinavir plus ritonaviren_US
dc.subjectMeal conditionsen_US
dc.subjectHIV-infected Ugandan adultsen_US
dc.titleSteady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adultsen_US
dc.typeArticleen_US
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