Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adults
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of acquired immune deficiency syndromes
Abstract
We investigated the effect of food on the steady-state pharmacokinetics of lopinavir and ritonavir
in 12 Ugandan patients receiving lopinavir co-formulated with ritonavir (LPV/r) tablets using a
cross-over design. Intensive pharmacokinetic sampling was performed seven days apart following
LPV/r dosing under moderate fat, high fat and fasted meal conditions. Lopinavir and ritonavir
concentrations were determined by liquid chromatography and tandem mass spectrometry.
Compared to the fasted state, a high fat meal reduced lopinavir and ritonavir area under the curve
(AUC) by 14% and 29%, respectively. With a moderate fat meal, AUC for both drugs was similar
to the fasted state.
Description
Keywords
Steady-state pharmacokinetics, Lopinavir plus ritonavir, Meal conditions, HIV-infected Ugandan adults
Citation
Lamorde, M., Byakika-Kibwika, P., Boffito, M., Nabukeera, L., Mayito, J., Ogwal-Okeng, J., ... & Merry, C. (2012). Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adults. Journal of acquired immune deficiency syndromes (1999), 60(3). doi:10.1097/QAI.0b013e3182567a35.