Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy

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dc.contributor.authorCarrico, Adam W.
dc.contributor.authorHunt, Peter W.
dc.contributor.authorEmenyonu, Nneka I.
dc.contributor.authorMuyindike, Winnie
dc.contributor.authorNgabirano, Christine
dc.contributor.authorCheng, Debbie M.
dc.contributor.authorWinter, Michael R.
dc.contributor.authorSamet, Jeffrey H.
dc.contributor.authorHahn, Judith A.
dc.date.accessioned2022-01-30T21:12:46Z
dc.date.available2022-01-30T21:12:46Z
dc.date.issued2015
dc.description.abstractAlcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated. HIV-positive persons who were not on anti-retroviral therapy (ART) completed the baseline assessment for a longitudinal study examining the association of alcohol use with HIV disease markers. Oversampling drinkers, baseline samples were tested for markers of monocyte activation (sCD14), inflammation (IL-6), and coagulation (D-dimer). We defined “unhealthy alcohol use” as testing positive using the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C; ≥ 3 for women and ≥ 4 for men) in the past 3 months or testing positive using a biomarker of heavy drinking, phophatidylethanol (PEth; ≥ 50 ng/ml). Multiple linear regression was used to examine the associations of unhealthy alcohol use with sCD14, Log10 IL-6, and D-dimer.en_US
dc.identifier.citationCarrico, A. W., Hunt, P. W., Emenyonu, N. I., Muyindike, W., Ngabirano, C., Cheng, D. M., ... & Hahn, J. A. (2015). Unhealthy alcohol use is associated with monocyte activation prior to starting antiretroviral therapy. Alcoholism: Clinical and Experimental Research, 39(12), 2422-2426. doi:10.1111/acer.12908.en_US
dc.identifier.other10.1111/acer.12908.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1643
dc.language.isoenen_US
dc.publisherClinical and Experimental Researchen_US
dc.subjectAlcoholen_US
dc.subjectHIV/AIDSen_US
dc.subjectImmune Activationen_US
dc.subjectMicrobial Translocationen_US
dc.titleUnhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapyen_US
dc.typeArticleen_US
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