Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Clinical and Experimental Research
Abstract
Alcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated.
HIV-positive persons who were not on anti-retroviral therapy (ART) completed the baseline assessment for a longitudinal study examining the association of alcohol use with HIV disease markers. Oversampling drinkers, baseline samples were tested for markers of monocyte activation (sCD14), inflammation (IL-6), and coagulation (D-dimer). We defined “unhealthy alcohol use” as testing positive using the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C; ≥ 3 for women and ≥ 4 for men) in the past 3 months or testing positive using a biomarker of heavy drinking, phophatidylethanol (PEth; ≥ 50 ng/ml). Multiple linear regression was used to examine the associations of unhealthy alcohol use with sCD14, Log10 IL-6, and D-dimer.
Description
Keywords
Alcohol, HIV/AIDS, Immune Activation, Microbial Translocation
Citation
Carrico, A. W., Hunt, P. W., Emenyonu, N. I., Muyindike, W., Ngabirano, C., Cheng, D. M., ... & Hahn, J. A. (2015). Unhealthy alcohol use is associated with monocyte activation prior to starting antiretroviral therapy. Alcoholism: Clinical and Experimental Research, 39(12), 2422-2426. doi:10.1111/acer.12908.