The Effect of Antiretroviral Therapy Initiation on the Vaginal Microbiome in HIV-Infected Women

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dc.contributor.authorLiu, Cindy M.
dc.contributor.authorPackman, Zoe R.
dc.contributor.authorAbraham, Alison G.
dc.contributor.authorSerwadda, David M.
dc.contributor.authorNalugoda, Fred
dc.contributor.authorAziz, Maliha
dc.contributor.authorProdger, Jessica L.
dc.contributor.authorKaul, Rupert
dc.contributor.authorKalibbala, Sarah
dc.contributor.authorGray, Ronald H.
dc.contributor.authorPrice, Lance B.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorTobian, Aaron A.R.
dc.contributor.authorReynolds, Steven J.
dc.date.accessioned2022-01-20T22:01:08Z
dc.date.available2022-01-20T22:01:08Z
dc.date.issued2021
dc.description.abstractThe impact of antiretroviral therapy (ART) initiation on the vaginal microbiome is unknown. This is of particular importance among women living in sub-Saharan Africa. Understanding this relationship could help elucidate if and how the host immune system interacts with the vaginal microbiome. Methods. The vaginal microbiome of HIV-1/HSV-2-coinfected women (n = 92) in Uganda was evaluated from self-collected vaginal swabs 1 month pre-ART and at 4 and 6 months post–ART initiation. The vaginal microbiome was characterized by 16S rRNA genebased sequencing and quantitative polymerase chain reaction. Vaginal community state types (CSTs) were identified using proportional abundance data. Changes in microbiome composition were assessed with permutational analyses of variance (PerMANOVA).en_US
dc.identifier.citationGrabowski, M. K., Patel, E. U., Nakigozi, G., Ssempijja, V., Ssekubugu, R., Ssekasanvu, J., ... & Reynolds, S. J. (2021). Prevalence and Predictors of Persistent Human Immunodeficiency Virus Viremia and Viral Rebound After Universal Test and Treat: A Population-Based Study. The Journal of infectious diseases, 223(7), 1150-1160. DOI: 10.1093/ofid/ofz328en_US
dc.identifier.other10.1093/ofid/ofz328
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1368
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectAnaerobesen_US
dc.subjectHIVen_US
dc.subjectMicrobiomeen_US
dc.subjectVaginal dysbiosis.en_US
dc.titleThe Effect of Antiretroviral Therapy Initiation on the Vaginal Microbiome in HIV-Infected Womenen_US
dc.typeArticleen_US
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